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Structure. 1998 Mar 15;6(3):249-54.

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

Author information

1
Laboratory of Molecular Biophysics, University of Oxford, UK. davidb@biop.ox.ac.uk

Abstract

The crystal structure of the protein tyrosine phosphatase SHP-2 reveals the mechanism of auto-inhibition of phosphatase activity by its SH2 domains. Phosphotyrosine peptide stimulation of the phosphatase activity, resulting from peptide binding to the N-terminal SH2 domain, is linked to conformational changes within the protein, including an unprecedented allosteric transition of the N-terminal SH2 domain.

PMID:
9551546
DOI:
10.1016/s0969-2126(98)00027-6
[Indexed for MEDLINE]
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