Format

Send to

Choose Destination
J Neuropsychiatry Clin Neurosci. 1998 Winter;10(1):10-9.

Neuropsychiatric aspects of the adult variant of Tay-Sachs disease.

Author information

1
Department of Psychiatry, McMaster University Medical Centre, Hamilton, Ontario, Canada.

Abstract

Tay-Sachs disease (a GM2 gangliosidosis) is an inherited neuronal storage disease that can affect individuals across the age spectrum. Psychosis is reported in 30% to 50% of adult-onset patients, and many are misdiagnosed with schizophrenia. Mood disorders are present in more than 25% and cognitive impairment in more than 20%. Treatment of psychosis with neuroleptics may not have a favorable risk/benefit ratio, but treatment with benzodiazepines or electroconvulsive therapy may be efficacious. Metabolic diseases such as gangliosidosis are probably under-recognized as causes of neuropsychiatric illness. Increased awareness of these disorders will lead to accurate diagnosis, appropriate treatment selection, and genetic counseling.

PMID:
9547461
DOI:
10.1176/jnp.10.1.10
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center