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J Leukoc Biol. 1998 Apr;63(4):405-17.

Transcription factors that regulate monocyte/macrophage differentiation.

Author information

1
Departament de Fisiologia (Immunologia), Facultat de Biologia and Fundació August Pi i Sunyer, Universitat de Barcelona, Spain.

Abstract

Although all the cells in an organism contain the same genetic information, differences in the cell phenotype arise from the expression of lineage-specific genes. During myelopoiesis, external differentiating signals regulate the expression of a set of transcription factors. The combined action of these transcription factors subsequently determines the expression of myeloid-specific genes and the generation of monocytes and macrophages. In particular, the transcription factor PU.1 has a critical role in this process. We review the contribution of several transcription factors to the control of macrophage development.

PMID:
9544570
DOI:
10.1002/jlb.63.4.405
[Indexed for MEDLINE]

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