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Ann Hum Genet. 1997 Nov;61(Pt 6):491-6.

Genetic analysis of a Japanese patient with butyrylcholinesterase deficiency.

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  • 1Department of Biochemistry, Kawasaki Medical School, Kurashiki, Japan.


A patient (64-year-old, male) with familial cholinesterasemia caused by BChE deficiency was studied. DNA sequence analysis of all exons identified a point mutation, an A-->G transition at codon 128, resulting in a Tyr-->Cys substitution. The propositus showed extremely low BChE activity, but his other family members (three individuals) showed from intermediate to normal BChE activity. An immunological method revealed the absence of BChE protein in serum of the propositus. Both PCR primer introduced restriction analysis (PCR-PIRA) and sequence analysis revealed all three family members to be heterozygotes for this mutation.

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