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J Affect Disord. 1998 Mar;48(2-3):157-61.

Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression.

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1
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

Abstract

BACKGROUND:

Testosterone replacement therapy is an effective treatment of some depressive symptoms in hypogonadal men, and may be an effective augmentation treatment for SSRI-refractory major depression in such men.

METHODS:

We treated five depressed men who had low testosterone levels and had not responded to an adequate SSRI trial with 400 mg testosterone replacement biweekly for 8 weeks. Four patients underwent single-blind placebo discontinuation. Patients were assessed at baseline and biweekly thereafter using the Hamilton Depression Rating Scale (HAM-D) and the Endicott Quality of Life Enjoyment and Satisfaction Scale (Q-LES-Q).

RESULTS:

Patients' mean age was 40 years, and mean testosterone level 277 ng/dl. All had a rapid and dramatic recovery from major depression following testosterone augmentation: mean 21-item HAM-D decreased from 19.2 to 7.2 by week 2, and to 4.0 by week 8; mean Q-LES-Q increased from 45% to 68%. Three of four subjects who underwent discontinuation of testosterone under single-blind placebo treatment began to relapse.

CONCLUSION:

Testosterone replacement therapy may be an effective treatment of depressive symptoms in some men, and warrants further research.

PMID:
9543205
[Indexed for MEDLINE]
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