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Eur J Clin Invest. 1998 Feb;28(2):145-50.

Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis.

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1
Centre de Recherches Pharmacologiques, Illkirch-Graffenstaden, France.

Abstract

BACKGROUND:

Modulation of cytokine secretion may be of interest in the treatment of Crohn's disease or ulcerative colitis.

METHODS:

The effect of three antioxidants - butylated hydroxyanisol, tetrahydropapaveroline and nordihydroguaiaretic acid - on the production of tumour necrosis factor (TNF), interleukin (IL) 1, IL-6 and IL-8 (measured by enzyme-linked immunosorbent assay) by peripheral mononuclear cells and biopsies of inflamed colonic mucosa from inflammatory bowel disease patients were studied.

RESULTS:

We observed a decrease in IL-1 and IL-6 production by peripheral mononuclear cells from inflammatory bowel disease patients (approximately 50% of control). The three drugs did not decrease IL-6 and IL-8 secretion by colonic biopsies, whereas they did inhibit IL-1 and, to some degree, TNF production. The cytokine-inhibitory effect of antioxidants seems to be more pronounced in ulcerative colitis than in Crohn's disease.

CONCLUSION:

Our results suggest that the studied antioxidants, or related compounds, may be of interest in inflammatory bowel disease treatment.

PMID:
9541129
[Indexed for MEDLINE]
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