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FEBS Lett. 1998 Mar 20;425(1):7-13.

Identification and characterization of a novel member of the dystrobrevin gene family.

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  • 1Telethon Institute of Genetics and Medicine (TIGEM), Milan, Italy.


A new member of the dystrobrevin gene family was identified using a bioinformatics approach. Sequence analysis indicates that this gene, named DTN-B, is highly homologous to the rabbit A0, the previously described dystrobrevin (DTN), Torpedo 87 kDa and to the C-terminus of dystrophin. The coiled-coil domain, shown to be the site of interaction between dystrobrevins and dystrophin, is highly conserved. Immunostaining studies indicate that DTN-B and DTN expression is absent in affected muscle fibers from DMD patients and carriers.

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