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Am J Obstet Gynecol. 1998 Mar;178(3):504-10.

Characteristics of luteinizing hormone secretion in younger versus older premenopausal women.

Author information

1
Department of Obstetrics and Gynecology, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298, USA.

Abstract

OBJECTIVES:

The objectives of this study were to document specific attributes of pulsatile luteinizing hormone secretion in middle-aged women before discernible alterations in their menstrual cycles and to compare the results to corresponding data obtained in younger women.

STUDY DESIGN:

After documenting normal cycle length, biphasic basal body temperatures, and normal midluteal progesterone in younger and middle-aged women during an initial cycle, daily blood samples and samples withdrawn at 10-minute intervals for 8 hours during the midfollicular phase were obtained during a subsequent cycle.

RESULTS:

Assessment of luteinizing hormone pulses with the pulse detection algorithm Cluster demonstrated a prolonged interpulse interval and increased pulse width in the older women. Assessment of luteinizing hormone secretory bursts and half-life with the deconvolution analysis procedure demonstrated a prolonged interburst interval and half-life in the older women. Appraisal of approximate entropy revealed greater orderliness of luteinizing hormone release in the older women.

CONCLUSIONS:

Middle-aged women exhibit alterations in hypothalamic-pituitary function that may account in part for age-related changes in reproductive potential.

PMID:
9539517
DOI:
10.1016/s0002-9378(98)70429-6
[Indexed for MEDLINE]

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