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Oncol Rep. 1998 May-Jun;5(3):649-52.

Serum levels of interleukin-6 as a prognostic factor in advanced non-small cell lung cancer.

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Dipartimento di Internistica Clinica e Sperimentale, Cattedra di Oncologia Medica, Seconda Universita di Napoli, c/o II Policlinico, via S. Pansini n. 5, Naples, 80131, Italy.


Serum levels of interleukin-6 (IL-6) were evaluated in a group of advanced non-small cell lung cancer (NSCLC) patients using an enzyme-linked immunosorbent assay. The data were related to clinical status and to cisplatin-based chemotherapy response. The mean IL-6 concentrations were higher than the controls (p<0.0001); patients with metastatic tumor had higher levels than those with undisseminated disease (p<0.006). Tumor progression was associated with an increase of IL-6 levels. Patients who responded to chemotherapy had lower serum IL-6 levels compared with unresponsive patients (p<0.0001). These data suggest that NSCLC patients with high levels of IL-6 have a worse clinical outcome and may manifest resistance to cisplatin chemotherapy.

[Indexed for MEDLINE]

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