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FEBS Lett. 1998 Mar 6;424(1-2):41-5.

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling.

Author information

1
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA.

Abstract

TRAIL/Apo-2L induces rapid apoptosis of a variety of tumor cell lines. A family of tumor necrosis factor receptor-related molecules have been identified as receptors for TRAIL. Herein, we report the identification of another member of the TRAIL receptor family, TRUNDD (TRAIL receptor with a truncated death domain). The TRUNDD transcript was detected in multiple human tissues. TRUNDD is highly homologous to all known TRAIL receptors and has an extracellular TRAIL-binding domain but lacks a functional intracellular death domain and does not induce apoptosis. Consistent with an inhibitory role, ectopic expression of TRUNDD attenuated TRAIL-induced apoptosis in mammalian cells.

PMID:
9537512
DOI:
10.1016/s0014-5793(98)00135-5
[Indexed for MEDLINE]
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