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J Antimicrob Chemother. 1998 Feb;41(2):293-6.

In-vitro activities of paromomycin and lasalocid evaluated in combination against Cryptosporidium parvum.

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Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.


Using a chemiluminescence immunoassay, paromomycin and lasalocid were shown to inhibit Cryptosporidium parvum growth in Madin-Darby canine kidney cells in a concentration-dependent manner. The median effective concentrations (EC50s) for paromomycin and lasalocid were 1184 mg/L and 0.4 mg/L, respectively. Neither drug was cytotoxic to host cells at concentrations up to five times their EC50s. Drug combination studies were conducted and the resulting data were analysed by the median-effect principle and combination index method. Statistically significant synergy was observed when combinations of paromomycin and lasalocid were used at ratios of 5000:1 and 2500:1. A possible mechanism for synergy is discussed.

[Indexed for MEDLINE]

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