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Fertil Steril. 1998 Mar;69(3):474-7.

Inhibin-B: the physiologic basis of the clomiphene citrate challenge test for ovarian reserve screening.

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1
Department of Obstetrics and Gynecology, Bethesda Hospital, Cincinnati, Ohio, USA.

Abstract

OBJECTIVE:

To determine inhibin-B concentrations during ovarian reserve screening in women with normal and diminished ovarian reserve as determined by the clomiphene citrate challenge test.

DESIGN:

Retrospective.

SETTING:

Tertiary fertility center.

PATIENT(S):

Women undergoing ovarian reserve screening for a routine fertility evaluation.

INTERVENTION(S):

Clomiphene citrate challenge test.

MAIN OUTCOME MEASURE(S):

Inhibin-B concentrations on menstrual days 3 and 10.

RESULT(S):

Nineteen patients with normal ovarian reserve and 15 with diminished ovarian reserve had serum inhibin-B concentrations determined during ovarian reserve screening. For all patients, day 10 inhibin-B concentrations were higher than day 3. Women with normal ovarian reserve had higher inhibin-B concentrations on both days 3 and 10 than women with diminished ovarian reserve. Inhibin-B concentrations demonstrated a negative correlation with FSH levels on both cycle days 3 and 10 and a positive correlation with E2 on cycle day 10.

CONCLUSION(S):

Women with diminished ovarian reserve during ovarian reserve screening had reduced granulosa cell inhibin-B production compared with women with normal ovarian reserve. The lower inhibin-B concentrations may be responsible for the elevated FSH concentrations and may be indicative of the aging follicular apparatus.

PMID:
9531880
[Indexed for MEDLINE]
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