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Cancer Genet Cytogenet. 1998 Apr 1;102(1):12-4.

Lipoblastoma: a case with t(7;8)(q31;q13).

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Department of Pediatric Hematology/Oncology, Giannina Gaslini Institute, Genova, Italy.


Lipoblastoma is a rare benign adipose tumor which, in all of the cases so far described, presents an involvement of chromosome 8 in the region 8q11-13. We hereby report the results of the second case of lipoblastoma studied by fluorescence in situ hybridization (FISH), in a 13-month-old boy. An abnormal karyotype 46,XY,t(7;8)(q31;q13) was found in 90% of the metaphases examined, in agreement with the previously reported observations. We suggest the region 8q11-13 may contain a relevant locus for lipoblastoma origin.

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