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Semin Immunol. 1998 Feb;10(1):15-23.

Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice.

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Department of Immunology, Mayo Clinic and Medical School, Rochester, MN 55905, USA.


Human spondyloarthropathies have a strong association with the presence of MHC class I allele, HLA-B27. Spondyloarthropathies occur predominantly in males and are usually triggered by an infection with an enterobacteria. Similar to human disease, experimental animals with HLA-B27 transgene also develop spontaneous inflammatory disease. In addition to HLA-B27, the role of environmental antigens has also been implicated in the animal models. How bacteria interact with HLA-B27 is not yet clearly understood. By breeding HLA-B27 transgenic mice with various transgenic and knock out mice, we investigated the immune mechanism in this inflammatory disease. In this review, we will summarize our recent findings and propose a hypothesis.

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