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Curr Opin Genet Dev. 1998 Feb;8(1):95-102.

Beta-catenin: a key mediator of Wnt signaling.

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Howard Hughes Medical Institute, Department of Developmental Biology, Backman Center, Stanford University Medical Center, California 94305, USA.


Beta-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. beta-catenin activity is controlled by a large number of binding partners that affect the stability and the localization of beta-catenin and is thereby able to participate in such varying processes as gene expression and cell adhesion. Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors.

[Indexed for MEDLINE]

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