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Curr Opin Genet Dev. 1998 Feb;8(1):55-62.

Mechanism of activation and function of protein kinase B.

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MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, UK.


The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.

[Indexed for MEDLINE]

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