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Infect Immun. 1998 Apr;66(4):1800-2.

Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha.

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1
Department of Surgery, University of Florida College of Medicine, Gainesville 32610, USA.

Abstract

Plasma leptin and ob gene mRNA levels were increased in mice following bacterial peritonitis, and blocking an endogenous tumor necrosis factor alpha (TNF-alpha) response blunted the increase. However, plasma leptin concentrations did not correlate with the associated anorexia. We conclude that leptin expression is under partial regulatory control of TNF-alpha in peritonitis, but the anorexia is not dependent on increased leptin production.

PMID:
9529118
PMCID:
PMC108125
[Indexed for MEDLINE]
Free PMC Article
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