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Planta Med. 1998 Mar;64(2):176-8.

Aloe-emodin effects on arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori.

Abstract

Arylamine N-acetyltransferase (NAT) activities with p-aminobenzoic acid (PABA) and 2-aminofluorene (AF) were determined in H. pylori collected from peptic ulcer patients. Cytosols or suspensions of H. pylori with or without different concentrations of aloe-emodin co-treatment showed different percentages of AF and PABA acetylation. The data indicate that there was decreased NAT activity associated with increased aloe-emodin in H. pylori cytosols. Inhibition of growth study from H. pylori demonstrated that aloe-emodin elicited dose-dependent growth inhibition in H. pylori cultures. The report is the first finding of aloe-emodin inhibition of arylamine NAT activity in a strain of H. pylori.

PMID:
9525111
DOI:
10.1055/s-2006-957399
[Indexed for MEDLINE]

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