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Biol Chem. 1998 Feb;379(2):225-9.

A hirudin-sensitive, growth-related proteinase from human fibroblasts.

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School of Biological Sciences, University of Auckland, New Zealand.


We have identified a hirudin-sensitive proteinase from human fibroblasts. Inhibition of this enzyme results in partial inhibition of cell growth in culture. The enzyme has a molecular weight of about 38000, and can be isolated by affinity chromatography with a hirudin-agarose matrix. The enzyme is apparently not closely related to thrombin, but does show a high level of amino acid sequence homology with fragments of a protein isolated from the synovial fluid of rheumatoid arthritis patients, which acts as a mitogen for human T lymphocytes.

[Indexed for MEDLINE]

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