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Curr Opin Immunol. 1998 Feb;10(1):50-5.

The mannose receptor is a pattern recognition receptor involved in host defense.

Author information

1
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. pstahl@cellbio.wastl.edu

Abstract

The mannose receptor recognizes the patterns of carbohydrates that decorate the surfaces and cell walls of infectious agents. This macrophage and dendritic cell pattern-recognition receptor mediates endocytosis and phagocytosis. The mannose receptor is the prototype of a new family of multilectin receptor proteins (membrane-spanning receptors containing eight-ten lectin-like domains, which appear to play a key role in host defense) and provides a link between innate and adaptive immunity. Recent advances include the identification of three new members of the mannose receptor family, additional work on defining the molecular requirements for sugar binding, a role for the mannose receptor in antigen presentation of lipoglycan antigens and evidence that the mannose receptor is associated with a signal transduction pathway leading to cytokine production.

PMID:
9523111
[Indexed for MEDLINE]

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