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Genome Res. 1998 Mar;8(3):211-21.

Software for constructing and verifying pedigrees within large genealogies and an application to the Old Order Amish of Lancaster County.

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Laboratory for Genetic Disease Research (LGDR)/National Human Genome Research Institute (NHGRI)/National Institutes of Health (NIH), Bethesda, Maryland 20892, USA.


This paper describes PedHunter, a software package that facilitates creation and verification of pedigrees within large genealogies. A frequent problem in medical genetics is to connect distant relatives with a pedigree. PedHunter uses methods from graph theory to solve two versions of the pedigree connection problem for genealogies as well as other pedigree analysis problems. The pedigrees are produced by PedHunter as files in LINKAGE format ready for linkage analysis. PedHunter uses a relational database of genealogy data, with tables in specified format, for all calculations. The functionality and utility of PedHunter are illustrated by examples using the Amish Genealogy Database (AGDB), which was created for the Old Order Amish community of Lancaster County, Pennsylvania.

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