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Arch Dermatol. 1998 Mar;134(3):301-4.

Focal hyperhidrosis: effective treatment with intracutaneous botulinum toxin.

Author information

1
Department of Neurology, Bayerische Julius-Maximilians-Universit├Ąt, W├╝rzburg, Germany.

Abstract

OBJECTIVE:

To evaluate the effect of intracutaneous injections of botulinum toxin type A on excessive focal hyperhidrosis.

DESIGN:

Therapeutic before-and-after trial over 4 months.

SETTING:

Neurological and dermatological university departments.

PATIENTS:

Eleven patients with excessive axillary, palmar, or plantar hyperhidrosis fulfilling the following criteria: (1) local and systemic drug therapy had failed to improve their symptoms; (2) the patients were severely disabled with respect to their occupation and social activities; and (3) a successful treatment by botulinum toxin would obviate the need for destructive surgical procedures.

INTERVENTIONS:

Three mouse units of botulinum toxin (Botox) per 4-cm2 skin area was injected intracutaneously in 16 axillae, 8 palms, and 2 soles.

MAIN OUTCOME MEASURES:

Reduction of hyperhidrosis as documented by the Minor iodine-starch test and gravimetrical assessment of local spontaneous sweat production measured over 1 minute.

RESULTS:

In all patients, botulinum toxin completely abolished sweating in the injected areas (P<.001) within 3 to 7 days. No relevant adverse effects occurred and no clinical recurrence of hyperhidrosis was observed within the follow-up period of up to 5 months. Occasionally, subclinical reactivation of sweat gland function was observed 4 months after treatment.

CONCLUSIONS:

Intracutaneous botulinum toxin seems preferable to any hitherto used conservative or surgical procedures and may become the therapy of choice in pathological focal hyperhidrosis.

PMID:
9521028
DOI:
10.1001/archderm.134.3.301
[Indexed for MEDLINE]

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