Format

Send to

Choose Destination
Structure. 1998 Feb 15;6(2):127-33.

Isoprenoid biosynthesis: manifold chemistry catalyzed by similar enzymes.

Author information

1
Institut für Organische Chemie und Biochemie, Freiburg, Germany.

Abstract

Isoprenoids comprise a family of more than 23,000 natural products, among them the precursors of cholesterol and taxol. The structures of three isoprenoid-cyclizing enzymes have recently been determined and here are placed in the greater context of isoprenoid biosynthesis. On the basis of reaction mechanisms, a subdivision into class I and class II enzymes is proposed. The chain folds of these enzymes also appear to fall into the same two distinct classes, suggesting that class I and class II enzymes have evolved separately.

PMID:
9519404
DOI:
10.1016/s0969-2126(98)00015-x
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center