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AIDS. 1998 Feb 12;12(3):279-84.

Antiviral effect of double and triple drug combinations amongst HIV-infected adults: lessons from the implementation of viral load-driven antiretroviral therapy.

Author information

1
British Columbia Centre for Excellence in HIV/AIDS, St Paul's Hospital, University of British Columbia, Vancouver, Canada. bobhogg@hivnet.ubc.ca

Abstract

OBJECTIVE:

To study the antiviral effect and predictors of response to two- and three-drug regimens amongst antiretroviral-naive individuals using an intent-to-treat analysis.

MAIN OUTCOME MEASURE:

Suppression of plasma viral load to < 500 copies/ml.

PATIENTS:

A total of 420 (264 double drug, 156 triple drug) individuals in a province-wide treatment programme were studied.

RESULTS:

A decrease in plasma viral load to < 500 copies/ml was documented in 197 (47%) subjects. This was independently associated with a lower baseline plasma viral load (odds ratio, 3.67; 95% confidence interval, 2.13-6.30) and initiation onto a three-drug regimen (odds ratio, 3.86; 95% confidence interval, 2.24-6.66). Median plasma viral load failed to reach < 500 copies/ml and in fact rebounded in the two-drug group. In contrast, 91 (58%) subjects receiving three drugs reached < 500 copies/ml during the study period.

CONCLUSION:

These results support the use of powerful triple drug regimens as initial therapy in HIV-infected individuals.

PMID:
9517990
[Indexed for MEDLINE]
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