Send to

Choose Destination
J Am Soc Echocardiogr. 1998 Feb;11(2):138-48.

Rapid estimation of regurgitant volume by the proximal isovelocity surface area method in mitral regurgitation: Can continuous-wave Doppler echocardiography be omitted?

Author information

Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.


The proximal isovelocity surface area (PISA) method is accurate for quantitating mitral regurgitation but requires recording both mitral maximal and integrated jet velocities using the same continuous-wave Doppler jet signal. In 272 consecutive patients with isolated mitral regurgitation, the mean ratio of maximal to integral of velocity had a narrow range of variation (mean +/- SD, 3.25 +/- 0.47). The estimated regurgitant volume, calculated as regurgitant flow/3.25, showed an excellent correlation with reference regurgitant volumes (r = 0.96 and r = 0.97; standard error of the estimate, 11 ml; both p < 0.0001), with limited overestimation and high sensitivity and specificity for severe mitral regurgitation. The estimated regurgitant volume is a useful measurement in patients in whom the continuous-wave Doppler signal of mitral regurgitation cannot be obtained.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center