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Biol Psychiatry. 1998 Mar 1;43(5):315-9.

Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients.

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1
University Department of Psychiatry, Sheffield, United Kingdom.

Abstract

BACKGROUND:

It has been hypothesized that depletion of cell membrane n3 polyunsaturated fatty acids (PUFA), particularly docosahexanoic acid (DHA), may be of etiological importance in depression.

METHODS:

We measured the fatty acid composition of phospholipid in cell membranes from red blood cells (RBC) of 15 depressive patients and 15 healthy control subjects.

RESULTS:

Depressive patients showed significant depletions of total n3 PUFA and particularly DHA. Incubation of RBC from control subjects with hydrogen peroxide abolished all significant differences between patients and controls.

CONCLUSIONS:

These findings suggest that RBC membranes in depressive patients show evidence of oxidative damage. Possible interpretations, and implications for the etiology and treatment of depression, are discussed.

PMID:
9513745
[Indexed for MEDLINE]
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