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FEBS Lett. 1998 Feb 20;423(2):143-8.

African origin of GB virus C/hepatitis G virus.

Author information

1
Second Department of Medicine, Nagoya City University Medical School, Kawasumi, Mizuho, Japan.

Abstract

Ninety-four GB virus C/hepatitis G virus (GBV-C/ HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV-A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBV-C/HGV.

PMID:
9512347
DOI:
10.1016/s0014-5793(98)00083-0
[Indexed for MEDLINE]
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