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Glycoconj J. 1997 Nov;14(7):785-93.

Host-cell-specific glycosylation of HIV-2 envelope glycoprotein.

Author information

1
Institute of Biochemistry, University of Giessen, Germany.

Abstract

Neutral complex-type N-glycans of the envelope glycoprotein 120 of HIV-2, propagated in different host cells, display cell-type specific variations. In order to identify typical structural elements, glycans were analysed by gel filtration, by enzymic sequencing and, in part, by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The characteristic substituents of di- tri- and tetraantennary carbohydrate units thus observed include N-acetyllactosamine repeats, bisecting N-acetylglucosamine and fucose linked to the chitobiose core as well as to N-acetyllactosamine antennae. Each glycoprotein preparation displayed a characteristic set of glycoforms.

PMID:
9511983
DOI:
10.1023/a:1018577619036
[Indexed for MEDLINE]

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