Send to

Choose Destination
J Antimicrob Chemother. 1998 Jan;41(1):115-8.

Unusual tazobactam-sensitive AmpC beta-lactamase from two Escherichia coli isolates.

Author information

Department of Medical Microbiology, St Bartholomew's, London, UK.


Two Escherichia coli isolates were studied. MIC patterns and hydrolysis assays suggested that they hyperproduced AmpC beta-lactamase, but synergy between ceftazidime and tazobactam was greater than between ceftazidime and Ro 48-1256, whereas the converse pattern is typical of AmpC hyperproducers. Studies with purified beta-lactamase from one of the isolates confirmed that tazobactam was a 100-fold stronger inhibitor than for the classical E. coli AmpC enzyme. Moreover, in contrast to typical AmpC types, the new enzyme had greater affinity for cephaloridine than for benzylpenicillin.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center