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Trends Microbiol. 1998 Feb;6(2):76-83.

Genetic manipulation of antibiotic-producing Streptomyces.

Author information

1
DowElanco, Indianapolis, IN 46268, USA. rbaltz@dowelanco.com

Abstract

The genetic manipulation of Streptomyces species has been facilitated by the development of versatile cloning vectors, robust gene transfer systems and transposable elements. These molecular genetic tools have been used to construct antibiotic-producing strains with improved properties and recombinants for the production of hybrid glycopeptide and macrolide antibiotics, novel anthelminthic agents and novel cytotoxic anthracyclines.

PMID:
9507643
DOI:
10.1016/S0966-842X(97)01161-X
[Indexed for MEDLINE]
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