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J Pediatr. 1998 Feb;132(2):352-4.

Omeprazole in infants with cimetidine-resistant peptic esophagitis.

Author information

1
Department of Pediatrics, Virga Jesse Hospital, Hasselt, Belgium.

Abstract

Twelve neurologically normal infants (age 2.9+/-0.9 months) with peptic esophagitis (grade 2) who did not respond to cimetidine (in addition to positioning, cisapride, and Gaviscon) were treated with omeprazole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazole was evaluated in all infants by clinical assessment and endoscopy before and after treatment and by 24-hour gastric pH monitoring during treatment in seven infants. Omeprazole therapy led to a marked decrease in symptoms, endoscopic and histologic signs of esophagitis, and intragastric acidity.

PMID:
9506656
DOI:
10.1016/s0022-3476(98)70460-3
[Indexed for MEDLINE]

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