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Fungal Genet Biol. 1998 Feb;23(1):1-17.

Cytochrome P450 enzyme systems in fungi.

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Department of Molecular Genetics and Gene Technology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands.


The involvement of cytochrome P450 enzymes in many complex fungal bioconversion processes has been characterized in recent years. Accordingly, there is now considerable scientific interest in fungal cytochrome P450 enzyme systems. In contrast to S. cerevisiae, where surprisingly few P450 genes have been identified, biochemical data suggest that many fungi possess numerous P450 genes. This review summarizes the current information pertaining to these fungal cytochrome P450 systems, with emphasis on the molecular genetics. The use of molecular techniques to improve cytochrome P450 activities in fungi is also discussed.

[Indexed for MEDLINE]

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