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Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3042-7.

Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3.

Author information

1
University of California, Irvine, Irvine, CA 92697-4025, USA.

Abstract

Nasopharyngeal carcinoma is a malignancy that is prevalent among populations from Southeast Asia. Epidemiological studies indicate that genetic predisposition, Epstein-Barr virus, and environmental conditions may play a role in determining incidence. Molecular studies have implicated a tumor suppressor gene(s) on the short arm of chromosome 3. In this study we provide functional evidence, via monochromosome transfer, for a tumor suppressor gene(s) activity in chromosome 3p21.3.

PMID:
9501212
PMCID:
PMC19691
DOI:
10.1073/pnas.95.6.3042
[Indexed for MEDLINE]
Free PMC Article

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