Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1998 Feb 24;243(3):653-6.

Regulation of nuclear calcium uptake by inositol phosphates and external calcium.

Author information

1
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.

Abstract

Factors affecting Ins(1,3,4,5)P4-mediated nuclear Ca2+ uptake are investigated, which include Ins(1,3,4,5)P4 receptor ligand specificity and free external Ca2+ concentrations. Among various inositol phosphates examined, Ins(1,3,4,5)P4, Ins(3,4,5,6)P4, and Ins(1,3,4,5,6)P5 can also stimulate 45Ca2+ influx into isolated rat liver nuclei by activating the Ins(1,3,4,5)P4 receptor-mediated Ca2+ uptake into the nucleus. The EC50 values of these polyphosphates range between 200 and 300 nM, which are 3-4 folds higher than that of Ins(1,3,4,5)P4. It is plausible that these polyphosphates in conjunction with Ins(1,3,4,5)P4 take part in the regulation of nuclear Ca2+ uptake in view of their intracellular levels during cell activation. Moreover, the inositol phosphate-induced Ca2+ uptake is facilitated by increasing Ca2+ levels in the uptake milieu, suggesting a possible link between cytosolic and nuclear Ca2+ signals through the Ins(1,3,4,5)P4 receptor.

PMID:
9500990
DOI:
10.1006/bbrc.1998.8161
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center