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Infect Dis Clin North Am. 1998 Mar;12(1):39-46.

Group O human immunodeficiency virus-1 infections.

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Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.


Human immunodeficiency viruses (HIV), the cause of AIDS, have remarkable genetic diversity. Among the HIV-1 viruses are the "major" (group M) HIV-1 subtypes and genetic "outliers" that have been designated as group O viruses. Group O viruses are most prevalent in parts of Africa, although they have also been reported in Europe and the United States and are associated with AIDS. Because group O viruses are so highly divergent, tests designed to detect group M viruses may be unreliable in the diagnosis of group O infection. Modification of these tests are needed to protect the safety of the blood supply.

[Indexed for MEDLINE]

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