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Biochem J. 1998 Mar 15;330 ( Pt 3):1241-8.

Isolation and characterization of advanced glycation end products derived from the in vitro reaction of ribose and collagen.

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Collagen Research Group, Division of Molecular and Cellular Biology, University of Bristol, Langford, Bristol BS18 7DU, U.K.


An amino acid component, NFC-1, when formed in vitro by the reaction of ribose and protein was shown to comprise a complex mixture of high and low molecular AGE compounds. Two low-molecular-weight components have been successfully isolated and their structure determined. These were alphaNFC-1 [Ndelta-(4-oxo-5-dihydroimidazol-2-yl)-l-ornithine] and betaNFC-1 a 4-imidazolon-2-yl derivative existing in three tautomeric forms. These imidazolone compounds have been shown to originate from the reaction of arginine with glyoxal and methylglyoxal, respectively. A third ninhydrin-positive AGE, gammaNFC-1, was shown to be composed of a number of chromatographically similar compounds which have not yet been characterized.

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