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Pediatr Neurol. 1998 Jan;18(1):67-70.

Adolescent case of Alexander disease: MR imaging and MR spectroscopy.

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Department of Pediatrics, Faculty of Medicine, University of Chiba, Japan.


A 17-year-old male was diagnosed as having Alexander disease from the clinical manifestations (psychomotor deterioration and megalencephaly), neuroradiologic findings (frontal dominant leukodystrophy), and elevation of alpha B-crystallin and heat shock protein 27 in the cerebrospinal fluid. He exhibited increased attenuation on computed tomography and T1 and T2 shortening on magnetic resonance imaging in the bilateral basal ganglia and thalamus. Some paramagnetic substances might be deposited in the basal ganglia and thalamus in the late stage of Alexander disease, at least 8 years after onset.

[Indexed for MEDLINE]

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