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Immunity. 1998 Feb;8(2):143-55.

Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice.

Author information

1
Institute for Genetics, University of Cologne, Germany.

Abstract

Patients with major histocompatibility complex class II (MHC-II) deficiency are known to carry mutations in either the RFX complex or the trans-activator CIITA. While the pivotal role of CIITA for MHC-II gene transcription is supported by the essential absence of MHC-II molecules in CIITA-deficient mice, we demonstrate here that RFX5-/- mice retain expression of MHC-II in thymic medulla, mature dendritic cells, and activated B cells. Nevertheless, RFX5-/- mice develop a severe immunodeficiency due to the lack of MHC-II in thymic cortex, failure of positive selection of CD4+ T cells, and absence of MHC-II on resting B cells and resident or IFNgamma-activated macrophages. This differential requirement for CIITA and RFX5 in subsets of antigen-presenting cells may be specific for the mouse; it may, however, also exist in humans without having been noticed so far.

PMID:
9491996
DOI:
10.1016/s1074-7613(00)80467-7
[Indexed for MEDLINE]
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