Format

Send to

Choose Destination
Br J Clin Pharmacol. 1998 Feb;45(2):176-8.

Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test.

Author information

1
Institute of Child Health, Alder Hey Children's Hospital, Liverpool.

Abstract

AIMS:

Carbamazepine is a known enzyme inducer. The aim of this study was to determine whether carbamazepine induces the metabolism of caffeine in children.

METHODS:

Children due to receive carbamazepine for epilepsy were recruited into the study. The caffeine breath test was carried out prior to the administration of carbamazepine and after a minimum of 2-3 weeks therapy. Five children were studied and they received 200-600 mg carbamazepine daily.

RESULTS:

The mean values of the 2 h cumulative labelled carbon dioxide were 3.47% before and 7.65% during carbamazepine. There was a significant increase in the percentage labelled caffeine exhaled as carbon dioxide during the administration of carbamazepine (Student's paired t-test, P < 0.05).

CONCLUSIONS:

The results suggest that carbamazepine induces the metabolism of caffeine by the CYP1A2 pathway in the children studied.

PMID:
9491835
PMCID:
PMC1873361
DOI:
10.1046/j.1365-2125.1998.00684.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center