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Parasitol Res. 1998;84(1):38-40.

Molecular cloning and expression of an anti-idiotype antibody mimicking a protective oligosaccharide of the parasite Schistosoma mansoni.

Author information

1
INSERM U167 Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France. karine.petitprez@pasteur-lille.fr

Abstract

Genes encoding the heavy and light chains of an anti-idiotype antibody (AB2) mimicking a protective oligosaccharide of Schistosoma mansoni were cloned and expressed as a single-chain Fv fragment. The expression in a functional state was tested using the AB1. A specific binding between sFv and AB1 was observed. Immunization with the recombinant AB2 indicates its capacity to elicit anti-S. mansoni antibodies.

PMID:
9491424
[Indexed for MEDLINE]

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