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FEBS Lett. 1998 Jan 30;422(2):279-83.

Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms.

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Center for Biological Research, Neurobiology Unit, Roche Bioscience, Palo Alto, CA 94304, USA.


We have isolated and characterized from human prostate novel splice variants of the human alpha1A-adrenoceptor, several of which generate truncated products and one isoform, alpha(1A-4), which has the identical splice site as the three previously described isoforms. Long-PCR on human genomic DNA showed that the alpha(1A-4) exon is located between those encoding the alpha(1A-1) and alpha(1A-3) variants. CHO-K1 cells stably expressing alpha(1A-4) showed ligand binding properties similar to those of the other functional isoforms as well as agonist-stimulated inositol phosphate accumulation. Quantitative PCR analyses revealed that alpha(1A-4) is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.

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