Abstract
Norway rats were subjected to stress procedure of saline or hydrocortisone injections. The saline-treated rats revealed an increased level of the plasma corticosterone as opposed to hydrocortisone-treated ones. The modification of adrenocortical function with the stress in early postnatal life seems to be connected with changes in hypothalamic catecholamine synthesis and can be prevented with exogenous glycocorticoids.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Aging / drug effects*
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Aging / physiology
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Animals
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Brain / drug effects
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Brain / physiopathology
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Corticosterone / blood*
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Glucocorticoids / pharmacology*
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Hydrocortisone / pharmacology*
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Hypothalamo-Hypophyseal System / drug effects
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Hypothalamo-Hypophyseal System / physiology
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Male
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Pituitary-Adrenal System / drug effects
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Pituitary-Adrenal System / physiology
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Rats
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Receptors, Catecholamine / drug effects
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Receptors, Catecholamine / physiology
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Restraint, Physical
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Selection, Genetic
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Stress, Psychological / blood
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Stress, Psychological / etiology
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Stress, Psychological / physiopathology*
Substances
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Glucocorticoids
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Receptors, Catecholamine
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Corticosterone
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Hydrocortisone