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Pediatr Neurosurg. 1997 Jul;27(1):45-8.

Meningoencephalocele associated with Tripterygium wilfordii treatment.

Author information

1
Department of Neurosurgery, Showa University, Fujigaoka Hospital, Japan.

Abstract

We treated a male infant with occipital meningoencephalocele associated with the taking of Tripterygium wilfordii. The infant was delivered normally at 38 weeks of gestation with a huge cystic mass protruding from the occiput. He was diagnosed with occipital meningoencephalocele and cerebellar agenesis. His mother had taken T. wilfordii for rheumatoid arthritis early in her pregnancy. T. wilfordii is a herbal medicine used for rheumatoid arthritis and male contraception. Since its toxicity is high and its use during pregnancy is restricted, it is the most likely cause of this infant's anomalies.

PMID:
9486836
DOI:
10.1159/000121224
[Indexed for MEDLINE]

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