Format

Send to

Choose Destination
See comment in PubMed Commons below
J Am Acad Dermatol. 1998 Feb;38(2 Pt 1):207-20.

Use of serum soluble interleukin-2 receptor levels to monitor the progression of cutaneous T-cell lymphoma.

Author information

1
Department of Dermatology, School of Public Health, Allegheny University of the Health Sciences, Philadelphia, PA 19102, USA.

Abstract

BACKGROUND:

The serum concentration of soluble alpha chain of the interleukin-2 receptor (sIL-2R) correlates with tumor burden in cutaneous T-cell lymphoma (CTCL). Therefore the sIL-2R level may be useful to monitor the condition of patients treated with extracorporeal photopheresis or other treatments.

OBJECTIVE:

Our goal was to determine the utility of serum sIL-2R as a test in monitoring of patients with advanced CTCL.

METHODS:

Serum sIL-2R was measured serially in 36 patients with advanced CTCL treated with extracorporeal photopheresis and other modalities (interferon alfa, methotrexate, topical nitrogen mustard, electron beam).

RESULTS:

Serum concentrations of sIL-2R as well as lactate dehydrogenase (LDH) correlated strongly with lymph node size, but only sIL-2R correlated significantly with the severity of skin manifestations in erythrodermic patients. In addition, serum sIL-2R, but not LDH, was significantly higher in patients with nodal involvement. The level of sIL-2R also was significantly higher in patients with large-cell transformation in the skin or lymph nodes compared with patients without transformed disease. During treatment, serum concentrations of both serum sIL-2R and LDH correlated with changes in clinical status, but only sIL-2R showed statistically significant differences in mean levels for different relative global response scores. Pretreatment levels of both sIL-2R and LDH correlated significantly with survival, but only sIL-2R retained significance when both were entered into the Cox proportionate hazards model.

CONCLUSION:

The concentration of serum sIL-2R correlates well with disease status and is more useful than LDH or S├ęzary cell counts to monitor clinical change in patients with advanced CTCL. Moreover, our data suggest that sIL-2R is produced at a relatively low rate by tissue-based lymphoma cells, and that large-cell transformation in CTCL results in marked increase in sIL-2R production in some patients.

PMID:
9486676
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center