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Arthritis Rheum. 1998 Feb;41(2):256-62.

Genetic control of susceptibility to collagen-induced arthritis in T cell receptor beta-chain transgenic mice.

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1
University Hospital, Basel, Switzerland.

Abstract

OBJECTIVE:

To study the genes in the mouse background which predispose to the development of collagen-induced arthritis (CIA).

METHODS:

T cell receptor beta transgenic (TCRbetaL) mice that have a T cell repertoire that predisposes to the development of CIA were used. Classic genetic studies and microsatellite gene mapping were done in (SWR-betaL x DBA/1)F2 hybrid mice.

RESULTS:

Besides TCRbeta, major histocompatibility complex class II, and Igh-C, at least 2 other genes are absolutely required for CIA development in these mice. A strict association of CIA with the presence of functional complement C5 allele (Hc1) was found, suggesting that Hc1 or a closely linked gene might be one of these essential genes.

CONCLUSION:

This study provides new evidence of the pathogenetic role of complement C5 in CIA. Furthermore, these transgenic mice may facilitate molecular identification of other genes that predispose to CIA.

[Indexed for MEDLINE]

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