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Curr Opin Cell Biol. 1998 Feb;10(1):123-30.

Microtubules and actin filaments: dynamic targets for cancer chemotherapy.

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1
Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara 93106-9610, USA. jordan@lifesci.lscf.ucsb.edu

Abstract

Microtubules and actin filaments play important roles in mitosis, cell signaling, and motility. Thus these cytoskeletal filaments are the targets of a growing number of anti-cancer drugs. In this review we summarize the current understanding of the mechanisms of these drugs in relation to microtubule and actin filament polymerization and dynamics. In addition, we outline how, by targeting microtubules, drugs inhibit cell proliferation by blocking mitosis at the mitotic checkpoint and inducing apoptosis. The beta-tubulin isotype specificities of new anticancer drugs and the antitumor potential of agents that act on the actin cytoskeleton are also discussed.

PMID:
9484604
[Indexed for MEDLINE]
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