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Curr Opin Cell Biol. 1998 Feb;10(1):23-34.

The modular structure of actin-regulatory proteins.

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Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.


Filamentous actin structures possess unique biophysical and biochemical properties and are required for cell locomotion, cell division, compartmentalization and morphological processes. The site-specific assembly and disassembly of these structures are directed by actin-regulatory proteins. This article reviews how structural studies are now defining the atomic details of small modular domains present in actin-regulatory proteins responsible for crosslinking, severing and capping of actin filaments, as well as for localization of actin filament assembly. These studies have identified three modular strategies for the design of proteins that regulate the actin cytoskeleton.

[Indexed for MEDLINE]

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