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Trends Microbiol. 1998 Jan;6(1):23-7.

The role of CpG dinucleotides in DNA vaccines.

Author information

1
University of Iowa, Dept of Internal Medicine, Iowa City 52242, USA. arthur-krieg@uiowa.edu

Abstract

DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.

PMID:
9481820
DOI:
10.1016/S0966-842X(97)01145-1
[Indexed for MEDLINE]

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