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Ophthalmology. 1998 Feb;105(2):282-6.

The etiology of refractive changes at high altitude after radial keratotomy. Hypoxia versus hypobaria.

Author information

1
Ophthalmology Service, Madigan Army Medical Center, Tacoma, Washington 98431-5000, USA.

Abstract

OBJECTIVE:

Refractive changes at high altitude that occur after radial keratotomy (RK) may be caused by hypoxia or hypobaria.

DESIGN:

A prospective study was performed to evaluate the effects of hypoxia on RK and non-RK corneas.

PARTICIPANTS:

There were 20 RK and 20 control eyes.

INTERVENTION:

These eyes were subjected to ocular surface hypoxia using an air-tight goggle system at sea level for 2 hours.

MAIN OUTCOME MEASURES:

Keratometry, cycloplegic refraction, and pachymetry were evaluated using repeated measures analysis of variance.

RESULTS:

A significant hyperopic shift (P < 0.0001) and corneal flattening (P < 0.0013) occurred in all subjects with RK compared with those of control subjects. Corneal thickening occurred symmetrically in both groups.

CONCLUSIONS:

These results suggest that refractive changes in subjects with RK occur at high altitude as a direct result of corneal hypoxia.

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PMID:
9479288
DOI:
10.1016/s0161-6420(98)93094-9
[Indexed for MEDLINE]

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