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Nucleic Acids Symp Ser. 1997;(36):42-4.

Mitochondrial RNase P: the RNA family grows.

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  • 1University of Louisville, Department of Biochemistry, School of Medicine, KY 40292-0001, USA.


Recent results of biochemical approaches and genome sequencing approaches has extended the members of the family of mitochondrial RNase P RNA genes. So far all of them are AU rich, and most of their secondary structures are easier to predict than was the structure of the first mitochondrial RNase P RNA from S. cerevisiae. The recently sequenced protozoan R. americana mitochondrial gene displays many of the evolutionarily conserved primary sequence and secondary structure attributes of the well characterized bacterial RNase P RNAs. Continued addition of RNAs to this data base should allow increasingly informative alignments and an understanding of what structural elements are dispensable in the smallest mitochondrial RNAs. The only protein subunits identified to date are Rpm2p from S.cerevisiae and the homologous protein from S. douglasii.

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